human herpesvirus 8-related tumor Castleman disease multicentric Castleman disease https://www.malacards.org/card/hhv_8_associated_multicentric_castleman_disease https://www.malacards.org/card/multicentric_castleman_disease MCD UMLS:C1334815 GARD:0022310 multicentric Castleman's disease HHV-8-associated multicentric Castleman disease DOID:0111152 multicentric Angiofollicular lymphoid hyperplasia MONDO:0019754 idiopathic multicentric Castleman's disease multicentric plasma cell variant of Castleman's disease Orphanet:93686 MEDGEN:233197 icd11.foundation:1590444463 Orphanet:570438 NCIT:C27855 Human herpesvirus-8-associated multicentric Castleman disease Multicentric castleman disease (MCD) is an aggressive form of Castleman disease that mostly results from human herpesvirus 8 (HHV8) infection. It manifests by fever, diffuse lymphadenopathy, hepatosplenomegaly, Involvement of the respiratory system and increased C-reactive protein.