disease arises from structure disease arises from alteration in structure chromosome 3 (Human) ring chromosome 3 https://rarediseases.info.nih.gov/diseases/10839/ring-chromosome-3 https://www.malacards.org/card/ring_chromosome_3 chromosome 3 ring UMLS:C4707449 Ring chromosome 3 syndrome is a rare chromosomal anomaly syndrome with a highly variable phenotype principally characterized by pre- and postnatal growth retardation, short stature, developmental delay, mild to severe intellectual disability, microcephaly and mild dysmorphic features (incl. triangular face, dysplastic ears, upslanting palpebral fissures, epicanthic folds, broad nasal bridge, full nasal tip, long philtrum, downturned corners of the mouth, and micro/retrognathia). Additional manifestations reported include hypotonia, mild articular limitation, hearing loss, digital anomalies (i.e. clinodacytyly, brachydactyly), café-au-lait patches and hypospadias. MEDGEN:1643677 Ring 3 GARD:0010839 NCIT:C121982 Ring chromosome 3 syndrome MONDO:0019904 R3 SCTID:765486004 rose cluster 3 Ring chromosome type 3 Orphanet:96172 chromosome 3 disorder ring chromosome disorder