familial partial epilepsy familial focal epilepsy with variable foci https://github.com/monarch-initiative/mondo/issues/8455 https://www.epilepsydiagnosis.org/syndrome/ffevf-overview.html https://www.malacards.org/card/epilepsy_familial_focal_with_variable_foci_1_2 MEDGEN:348951 familial partial epilepsy with variable foci UMLS:C1858477 DOID:0081420 icd11.foundation:855404450 epilepsy, familial focal, with variable foci FFEVF MESH:C565785 Orphanet:98820 OMIMPS:604364 MONDO:0020310 GARD:0013295 Familial focal epilepsy with variable foci is a rare genetic epilepsy disorder characterized by autosomal dominant lesional and nonlesional focal epilepsy with variable penetrance. Focal seizures emanate from different cortical locations (temporal, frontal, centroparietal, parietal, parietaloccipital, occipital) in different family members, but for each individual a single focus remains constant throughout lifetime. Seizure type (tonic, tonic-clonic or hyperkinetic) and severity varies among family members and tends to decrease (but do not disappear) during adulthood. Many patients have an aura and show automatisms during diurnal seizures whereas others have nocturnal seizures. Most individuals are of normal intelligence but patients with intellectual disability, autistic spectrum disorder and obsessive-compulsive disorder have been described. SCTID:764522009 familial focal epilepsy with variable foci variable-age onset focal epilepsy syndrome