has material basis in germline mutation in disease has basis in disruption of disease caused by disruption of GATA1 adenosine deaminase activity hemolytic anemia congenital nonspherocytic hemolytic anemia inborn disorder of purine metabolism hemolytic anemia due to erythrocyte adenosine deaminase overproduction https://www.malacards.org/card/anemia_congenital_nonspherocytic_hemolytic_9 icd11.foundation:1200845933 OMIM:102730 MESH:C566314 UMLS:C1863235 GARD:0019669 Hemolytic anemia due to erythrocyte adenosine deaminase overproduction is a rare, genetic, hematologic disease characterized by mild, chronic hemolytic anemia (due to highly elevated adenosine deaminase activity in red blood cells resulting in their premature destruction), elevated reticulocyte count, splenomegaly and mild hyperbilirubinemia. Other cells and tissues are not affected. anemia, congenital, nonspherocytic hemolytic, 9 Orphanet:99138 DOID:0051008 MONDO:0020458 adenosine deaminase, elevated, hemolytic anaemia due to MEDGEN:400240 adenosine deaminase, elevated, hemolytic anemia due to OMIM:301083 anemia due to enzyme disorder