syndromic intellectual disability syndromic disease 48,XYYY syndrome https://github.com/monarch-initiative/mondo/issues/6878 https://www.malacards.org/card/48xyyy_syndrome 48,XYYY UMLS:C4518082 SCTID:733625003 Orphanet:99329 48,XYYY syndrome is a rare Y chromosome number anomaly that affects only males and is characterized by mild-moderate developmental delay (especially speech), normal to mild intellectual disability, large, irregular teeth with poor enamel, tall stature and acne. Radioulnar stenosis and clinodactyly have also been associated. Boys generally present normal genitalia, while hypogonadism and infertility is frequently reported in adult males. MONDO:0020469 MEDGEN:1371767 GARD:0011985 tetrasomy chromosome Y disorder