has material basis in germline mutation in CCDC88A PEHO syndrome PEHO-like syndrome https://github.com/monarch-initiative/mondo/issues/4521 https://www.malacards.org/card/peho_like_syndrome OMIM:617507 UMLS:C1850056 peho-like syndrome GARD:0016911 PEHO syndrome-like progressive encephalopathy with edema, hypsarrhythmia, and optic atrophy-like syndrome Orphanet:99807 PEHOL MEDGEN:337956 MONDO:0020495 PEHO-like syndrome is a rare, genetic neurological disease characterized by progressive encephalopathy, early-onset seizures with a hypsarrhythmic pattern, facial and limb edema, severe hypotonia, early arrest of psychomotor development and craniofacial dysmorphism (evolving microcephaly, narrow forehead, short nose, prominent auricles, open mouth, micrognathia), in the absence of neuro-ophthalmic or neuroradiologic findings. Poor visual responsiveness, growth failure and tapering fingers are also associated. hereditary neurological disease