leukodystrophy ravine syndrome https://www.malacards.org/card/ravine_syndrome progressive encephalopathy with severe infantile anorexia UMLS:C4275006 GARD:0003231 SCTID:715794009 Reunion island-anorexia-vomiting which is irrepressible-neurological signs syndrome MEDGEN:907744 Orphanet:99852 Ravine syndrome is an extremely rare genetic neurological disorder, reported in a small number of patients in a specific community on Reunion Island (Ravine region), characterized by infantile anorexia with irrepressible and repeated vomiting, acute brainstem dysfunction, severe failure to thrive, and progressive encephalopathy with MRI showing vanishing of medulla oblongata and cerebellar white matter and severe atrophy of pons, along with supra-tentorial periventricular white-matter hyperintensities and basal ganglia anomalies. icd11.foundation:451093599 MONDO:0020505