disease disrupts disease causes disruption of respiratory gaseous exchange by respiratory system lung disorder respiratory failure https://www.malacards.org/card/respiratory_failure UMLS:C1145670 MESH:D012131 respiratory failure SCTID:39871006 icd11.foundation:370028006 MEDGEN:257837 acute and chronic respiratory failure MONDO:0021113 ICD9:518.83 failure, respiratory DOID:11162 The significant impairment of gas exchange within the lungs resulting in hypoxia, hypercarbia, or both, to the extent that organ tissue perfusion is severely compromised. Causes include chronic obstructive pulmonary disease, asthma, emphysema, acute respiratory distress syndrome, pneumonia, pulmonary edema, pneumothorax, and congestive heart failure. Treatment requires intubation and mechanical ventilation until the time the lungs recover sufficient function. NCIT:C26872 EFO:0009686 acute respiratory failure chronic respiratory failure