disease has location bone neoplasm Ewing sarcoma/peripheral primitive neuroectodermal tumor Ewing sarcoma/peripheral primitive neuroectodermal tumor of bone UMLS:C1333481 bone tissue Ewing sarcoma/peripheral primitive neuroectodermal tumor GARD:0025291 A spectrum of malignant tumors arising from the bone and characterized morphologically by the presence of small round cells. Ewing sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor. Ewing sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities. Pain and the presence of a mass are the most common clinical symptoms. MEDGEN:272598 bone tissue Ewing sarcoma/peripheral primitive neuroectodermal tumour MONDO:0021123 NCIT:C35871 Ewing sarcoma/peripheral primitive neuroectodermal tumor of bone Ewing's sarcoma/peripheral primitive neuroectodermal tumor of bone Ewing's sarcoma/peripheral primitive neuroectodermal tumour of bone bone tissue