disease has feature realized in response to realized in response to exposure to water Pruritus skin disorder aquagenic pruritus https://rarediseases.info.nih.gov/diseases/10278/aquagenic-pruritus ICD9:698.8 UMLS:C0406409 Aquagenic pruritus is a conditionin which contact with water of any temperature causes intense itching, without any visible skin changes. The symptoms may begin immediately after contact and can last for an hour or more. The cause of aquagenic pruritus is unknown; however, familial cases have been described. It may be a symptom of polycythemia vera or another underlying condition. Overall, treatment is a challenge. Antihistamines, UVB phototherapy, PUVA therapy and various medications have been tried with varying degrees of success. MONDO:0021913 aquagenic pruritus SCTID:238695001 icd11.foundation:1090223712 MEDGEN:98026