disease arises from structure disease arises from alteration in structure chromosome 22 (Human) trisomy 22 https://rarediseases.info.nih.gov/diseases/5335/trisomy-22 UMLS:C0265490 MONDO:0022759 SCTID:205655003 Trisomy 22 is a chromosome disorder in which an extra (third) copy of chromosome 22 is present in every cell of the body where there should normally only be two copies. This condition is commonly found in miscarriages, but only rarely in liveborn infants. Most affected individuals die shortly before or shortly after birth due to severe complications. Common features include an underdeveloped midface (midface hypoplasia)with flat/broad nasal bridge, malformed ears with pits or tags, cleft palate, hypertelorism (wide-spaced eyes), microcephaly and other cranial abnormalities, congenital heart disease, genital abnormalities, and intrauterine growth restriction (IUGR). MESH:C536799 MEDGEN:82711 GARD:0005335 chromosome 22 trisomy chromosome 22 disorder trisomy