Duane retraction syndrome Duane syndrome type 1 https://rarediseases.info.nih.gov/diseases/10763/duane-syndrome-type-1 https://www.malacards.org/card/duane_retraction_syndrome_1 DURS1 Duane retraction syndrome 1 DOID:0061027 GARD:0010763 Duane syndrome type 1 is the most common type of Duane syndrome, an eye movement disorder that is present at birth. People with Duane syndrome have restricted ability to move the affected eye(s) outward toward the ear (abduction) and/or inward toward the nose (adduction). The different types are distinguished by the eye movements that are most restricted. Duane syndrome type 1 is characterized by absent to very restricted abduction and normal to mildly restricted adduction. The eye opening (palpebral fissure) narrows and the eyeball retracts into the orbit with adduction. With abduction, the reverse occurs. One or both eyes may be affected. The majority of cases are sporadic (not inherited), while about 10% are familial. 70% of affected people do not have any other abnormalities at birth (isolated Duane syndrome). Treatment is mainly supportive and may include glasses or contact lenses for vision correction, eye patches, or surgery. OMIM:126800 UMLS:C0994516 MEDGEN:201329 SCTID:128082002 MONDO:0024265