has material basis in germline mutation in NOTCH1 aortic valve disorder familial bicuspid aortic valve aortic valve disease 1 https://github.com/monarch-initiative/mondo/issues/9236 MONDO:0024523 AOVD1 UMLS:C3887892 aortic valve disease caused by mutation in Notch1 NOTCH1 aortic valve disease DOID:0080333 GARD:0018470 MEDGEN:854610 OMIM:109730 aortic valve disease 1 Any aortic valve disease in which the cause of the disease is a mutation in the NOTCH1 gene. Notch1 aortic valve disease aortic valve disease caused by mutation in NOTCH1 NOTCH1-related AOS spectrum disorder