disease has location vulvar squamous neoplasm squamous cell carcinoma vulvar carcinoma vulvar squamous cell carcinoma https://www.malacards.org/card/vulva_squamous_cell_carcinoma NCIT:C4052 epidermoid carcinoma of vulva vulvar squamous cell cancer squamous cell carcinoma of the vulva MEDGEN:79201 mammalian vulva squamous cell carcinoma SCTID:254895003 GARD:0022005 vulvar squamous cell carcinoma vulvar epidermoid cell carcinoma vulva squamous cell carcinoma epidermoid cell carcinoma of vulva vulvar epidermoid carcinoma icd11.foundation:146824338 epidermoid carcinoma of the vulva An invasive squamous cell carcinoma arising from the vulva. Risk factors include the human papilloma virus and cigarette smoking. Precursor lesions include the vulvar intraepithelial neoplasia, lichen sclerosus with associated squamous cell hyperplasia, and chronic granulomatous vulvar disease such as granuloma inguinale. Symptoms include vulvar pruritus or irritation, discharge, bleeding, and pain. The following morphologic variants have been identified: keratinizing, non-keratinizing, basaloid, warty, verrucous, keratoacanthoma-like, and squamous cell carcinoma with tumor giant cells. Risk factors for recurrence include advanced stage, tumor diameter greater than 2.5 cm, multifocality, capillary-like space involvement, associated vulvar intraepithelial neoplasia grades 2 or 3, and margins of resection involved by tumor. (WHO, 2003) EFO:1000624 epidermoid cell carcinoma of the vulva UMLS:C0280856 DOID:2101 squamous cell carcinoma of vulva vulva epidermoid carcinoma MONDO:0024609 Orphanet:494448 vulva epidermoid cell carcinoma mammalian vulva