has material basis in germline mutation in TLR8 immunodeficiency disease immunodeficiency 98 with autoinflammation, X-linked https://github.com/monarch-initiative/mondo/issues/5261 https://www.malacards.org/card/immunodeficiency_98_with_autoinflammation_x_linked IMD98 MONDO:0024777 Orphanet:675628 UMLS:C5676883 X-linked immunodeficiency with autoinflammation immunodeficiency 98 with autoinflammation, X-linked An immunodeficiency disease characterized by onset of recurrent infections associated with lymphoproliferation and autoinflammation in the first decade of life. Mostly males are affected; carrier females may have mild symptoms. Laboratory studies show evidence of immune dysregulation, including hypogammaglobulinemia with reduced memory B cells, skewed T-cell subsets, increased levels of proinflammatory cytokines, activated T cells and monocytes, and autoimmune cytopenias, including neutropenia. MEDGEN:1805285 GARD:0027130 inflammation, neutropenia, bone marrow failure, and lymphoproliferation caused by TLR8 DOID:0061068 OMIM:301078