progressive muscular dystrophy distal myopathy oculopharyngodistal myopathy https://rarediseases.info.nih.gov/diseases/12592/oculopharyngodistal-myopathy oculopharyngeal distal myopathy oculopharyngodistal myopathy DOID:0081296 Oculopharyngodistal myopathy (OPDM) is a rare, adult-onset hereditary muscle disease. People with OPDM present with progressive eye and throat (pharyngeal) problems and involvement of the muscles of the lower legs and arms. Symptoms may include eyelid drooping (ptosis), swallowing difficulty, hoarse and nasal voice, leg and arm weakness, as well as muscle wasting in the face and in the legs and arms. Many people have respiratory problems due to respiratory muscle weakness. In rare cases, there is also hearing loss, as well as severe weakness in muscles of the forearms and thighs. As the disease progresses, other muscles may be affected. A blood exam may show an increased creatine kinase level and an abnormal EMG. Inheritance may be autosomal dominant or autosomal recessive. The specific cause is still unknown. UMLS:C1834014 Orphanet:98897 NANDO:1200219 icd11.foundation:1493269618 SCTID:763829004 OPDM OMIMPS:164310 MEDGEN:320250 GARD:0012592 MESH:C563508 MONDO:0025193