Leber hereditary optic neuropathy, autosomal recessive A form of mitochondrial disease that is caused by biallelic (autosomal recessive) mutations in nuclear‑encoded genes normally associated with mitochondrial Complex I subunits or assembly factors. It is characterized by sudden, painless central vision loss, optic nerve microangiopathy, and eventual atrophy in the absence of mtDNA mutations. OMIMPS:619382 Leber hereditary optic neuropathy, autosomal recessive GARD:0025532 MEDGEN:1786310 MONDO:0030309 UMLS:C5543589 LHONAR mitochondrial complex I deficiency, nuclear type