immunodeficiency disease immunodeficiency 88 https://github.com/monarch-initiative/mondo/issues/5261 https://www.malacards.org/card/immunodeficiency_88 Mendelian susceptibility to mycobacterial diseases due to TBX21 deficiency An autosomal recessive immune disorder characterized specifically by the development of disseminated mycobacterial disease following vaccination with BCG. The single patient described did not develop other clinical infectious diseases, although serology documented exposure to various viruses and bacteria. Immunologic workup shows defective development of certain innate immunologic cells and decreased production of gamma-interferon (IFNG). Additional manifestations include persistent reactive airway disease associated with increased production of Th2 cytokines. IMD88 DOID:0061058 OMIM:619630 UMLS:C5562026 MONDO:0030483 MEDGEN:1794236