has material basis in germline mutation in SERPING1 hereditary angioedema hereditary angioedema with C1Inh deficiency https://github.com/monarch-initiative/mondo/issues/4521 https://www.malacards.org/card/hereditary_angioedema_with_c1inh_deficiency Forms of hereditary angioedema that occur due to mutations in the gene for complement C1 inhibitor protein. Type I hereditary angioedema is associated with reduced serum levels of complement C1 inhibitor protein. Type II hereditary angioedema is associated with the production of a non-functional complement C1 inhibitor protein. MONDO:0033946 DOID:0080939 MEDGEN:1812520 angioedema, hereditary, 1 and 2 OMIM:106100 UMLS:C4552294 GARD:0022194 HAE1 angioedema, hereditary, type 1/2 Orphanet:528623 angioedema, hereditary, type I