syndromic disease frontonasal dysplasia-bifid nose-upper limb anomalies syndrome https://www.malacards.org/card/frontonasal_dysplasia_bifid_nose_upper_limb_anomalies_syndrome GARD:0022142 UMLS:C5567892 MONDO:0035018 Orphanet:521308 MEDGEN:1799315 A rare syndromic frontonasal dysplasia characterized by distinctive facial dysmorphic features including hypertelorism, almond-shaped palpebral fissures, nasal deformity with creased ridge, depressed or absent tip, and asymmetry and partial absence of nasal bones, and downturned corners of the mouth. Additional reported manifestations are limb anomalies (e. g. Poland anomaly, transverse limb agenesis, and anomalies of the hands and feet, such as camptodactyly, oligodactyly, clinodactyly, and syndactyly), frontonasal encephalocele, choanal atresia, congenital renal/cardiac malformations, and corpus callosum agenesis.