has material basis in germline mutation in CYP11B2 hereditary disease familial hypoaldosteronism early-onset familial hypoaldosteronism https://www.malacards.org/card/early_onset_familial_hypoaldosteronism GARD:0022243 Early-onset familial hyperreninemic hypoaldosteronism UMLS:C5680171 MEDGEN:1842560 Orphanet:556030 MONDO:0035320 A rare type of familial hypoaldosteronism characterized by early infantile onset of vomiting, diarrhea, severe dehydration, and failure to thrive. Analysis of plasma electrolytes shows hyponatremia, hyperkalemia, and acidosis. Plasma renin activity is elevated, and aldosterone levels are low. ICD10CM:E27.4 Severe aldosterone synthase deficiency