toxic encephalopathy brain disorder chronic bilirubin encephalopathy https://www.malacards.org/card/chronic_bilirubin_encephalopathy KSD BIND MONDO:0035345 Kernicterus spectrum disorder CBE GARD:0022198 A rare neurologic disease characterized by the chronic consequences of bilirubin toxicity in the globus pallidus, sub-thalamic nuclei, and other brain regions, after exposure to high levels of unconjugated bilirubin in the neonatal period. Symptoms begin after the acute phase of bilirubin encephalopathy in the first year of life, evolve slowly over several years, and include mild to severe extrapyramidal disturbances (especially dystonia and athetosis), auditory neuropathy spectrum disorder, and oculomotor and dental abnormalities. Bilirubin-induced neurological dysfunction UMLS:C5575229 MEDGEN:1806573 Orphanet:529808