autoimmune hepatitis seronegative autoimmune hepatitis https://www.malacards.org/card/seronegative_autoimmune_hepatitis UMLS:C5680121 Seronegative AIH MEDGEN:1804383 autoantibody-negative autoimmune hepatitis A form of autoimmune hepatitis characterized by the features of classic autoimmune hepatitis (i. e. clinical presentation as acute or chronic cryptogenic hepatitis, interface hepatitis on histological examination, elevated serum aspartate aminotransferase and alanine aminotransferase levels, hypergammaglobulinemia/elevated immunoglobulin G, therapeutic response to corticosteroids) in the absence of serum autoantibodies. Clinical manifestations include fatigue, malaise, arthralgia, jaundice, at later stages also signs of advanced chronic liver disease, such as spider nevi, caput medusae, splenomegaly, ascites, and palmar erythema. Presence of concurrent autoimmune diseases is frequently observed. MONDO:0035400 Orphanet:563589 GARD:0022253