obsolete lethal brain and heart developmental defects https://github.com/monarch-initiative/mondo/issues/4776 https://github.com/monarch-initiative/mondo/issues/7693 https://www.malacards.org/card/lethal_brain_and_heart_developmental_defects true Orphanet:580933 OBSOLETE. A rare genetic lethal multiple congenital anomalies/dysmorphic syndrome characterized by early intrauterine growth retardation, generalized edema, craniofacial dysmorphism (such as microcephaly, brachycephaly, frontal bossing, hypertelorism, short palpebral fissures, or absent nasal bone), cerebellar hypoplasia, sex reversal in male fetuses, congenital heart defects (including septal and valve defects and cardiomegaly), and late fetal loss. [Orphanet:580933] MONDO:0035581