syndromic intellectual disability intellectual disability pulmonary valve stenosis craniosynostosis Hordnes Engebretsen Knudtson syndrome https://github.com/monarch-initiative/mondo/issues/5588 UMLS:C2931100 GARD:0002736 acrobrachycephaly, ventriculomegaly, pulmonary stenosis, ectopic anus and mental retardation MEDGEN:419333 MESH:C536067 MONDO:0043099 acrobrachycephaly, ventriculomegaly, pulmonary stenosis, ectopic anus and intellectual disability cardiogenetic disease