lymphoma progressive transformation of germinal centers progressive transformation of Germinal centers MEDGEN:271018 GARD:0010712 progressive transformation of Germinal centres PTGC MESH:C548085 UMLS:C1514481 Editor note: represents a finding in NCIT NCIT:C38408 Progressive transformation of germinal centers is a condition in which a lymph node becomes very enlarged (lymphadenopathy). Typically, only one lymph node is affected, though PTGC can involve multiple lymph nodes. Theneck is the most common location of affected lymph nodes, but PTGC may also affect lymph nodes in the groin and armpits. adults are more frequently affected than children, but children have a higher chance of developing PTGC multiple times (recurrence). PTGC is not considered a precancerous condition, though it has been associated with Hodgkin lymphoma. MONDO:0043346