hypercalcemia disease humoral hypercalcemia of malignancy NCIT:C3496 SCTID:47709007 MEDGEN:56210 MONDO:0043455 UMLS:C0149911 Hypercalcemia generally develops as a late complication of malignancy; its appearance has grave prognostic significance. It remains unclear, however, whether death is associated with hypercalcemic crisis (uncontrolled or recurrent progressive hypercalcemia) or with advanced disease. Symptoms include central nervous system impairment such as delirium with prominent symptoms of personality change, cognitive dysfunction, disorientation, incoherent speech, and psychotic symptoms such as hallucinations and delusions, smooth muscle hypotonicity, and altered cardiovascular function. hypercalcemia of malignancy MESH:C562390 GARD:0025860 humoral hypercalcemia of malignancy paraneoplastic hematological syndrome