disease arises from feature disease has basis in feature heart disorder carcinoid tumor carcinoid heart disease SCTID:36222008 MEDGEN:762 heart disease, carcinoid MONDO:0043529 heart diseases, carcinoid MESH:D002275 carcinoid heart diseases Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation. UMLS:C0007093 carcinoid heart disease