type IV hypersensitivity disease type III hypersensitivity disease serum sickness serum sickness SCTID:72284000 serum Sicknesses sickness, serum icd11.foundation:715261250 MESH:D012713 MEDGEN:11390 MONDO:0043789 Delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest pain, and dyspnea. Certain drugs (e.g., antibiotics, anticancer agents, and anti-inflammatory medications) and infectious disorders (e.g., hepatitis B) may also cause serum sickness-like reaction. NCIT:C79718 Sicknesses, serum UMLS:C0036830 transfusion reaction due to serum protein reaction