intestinal disorder metabolic disease celiac disease collagenous sprue MEDGEN:137953 SCTID:61738006 non-gluten sensitive enteropathy syndrome Sprues, collagenous collagenous sprue A rare disorder affecting the digestive tract. Its cause is unclear but may be attributed, in part, to increased collagen synthesis without adequate fibrolysis. It is characterized histologically by atrophy of mucosal villi and crypts with extensive subepithelial collagen deposition. Clinical signs include nausea, vomiting, diarrhea and weight loss. Unlike celiac sprue (celiac disease), a gluten-free diet does not predict a certain regression of the disease. The clinical course follows a progression of malabsorption leading to nutritional deficiencies, small bowel ulceration/perforation, lymphoma and infection. Prognosis is usually dismal. NCIT:C45426 MONDO:0044092 icd11.foundation:562877246 sprue, collagenous MESH:D064068 collagenous Sprues UMLS:C0341299