obsolete skin/hair/eye pigmentation, variation in, 2 https://github.com/monarch-initiative/mondo/issues/4521 https://www.malacards.org/card/skin_hair_eye_pigmentation_variation_in_2 true Obsoleted as it represents a trait or is a legacy entry OMIM:266300 skin/hair/eye pigmentation 2, blond hair/fair skin SHEP2 MONDO:0044259 UV-induced skin damage OBSOLETE. Two types of melanin, the red pheomelanin and the black eumelanin, are present in human skin. {22:Valverde et al. (1995)} noted that eumelanin is photoprotective, whereas pheomelanin may contribute to UV-induced skin damage because of its potential to generate free radicals in response to ultraviolet radiation. Individuals with red hair have a predominance of pheomelanin in hair and skin and/or a reduced ability to produce eumelanin, which may explain why they fail to tan and are at risk from ultraviolet radiation. In mammals, the relative proportions of pheomelanin and eumelanin are regulated by melanocyte-stimulating hormone (see OMIM:176830), which acts via its receptor (MC1R) on melanocytes to increase the synthesis of eumelanin, and also via the product of the agouti locus (AGTI; OMIM:600201), which antagonizes this action. skin/hair/eye pigmentation 2, red hair/fair skin