realized in response to realized in response to exposure to water palmoplantar keratosis epidermal disease aquagenic palmoplantar keratoderma https://www.malacards.org/card/aquagenic_palmoplantar_keratoderma transient reactive papulotranslucent acrokeratoderma GARD:0012991 aquagenic syringeal acrokeratoderma aquagenic wrinkling of the hands MONDO:0044663 UMLS:C4087301 aquagenic keratoderma Transient reactive papulotranslucent acrokeratoderma Orphanet:498359 aquagenic wrinkling of the palms aquagenic palmoplantar keratoderma Aquagenic syringeal acrokeratoderma is a rare condition affecting the palms of the hands. It is characterized by the appearance or worsening of a palmar eruption, following brief exposure to water. The palmar eruption is made up of small, white or shining pimples that can conjoin into plaques. The feet are unaffected. Symptoms include a burning pain and a tightening sensation in the palms, as well as too much sweating. There are two variants. Most commonly, it is a temporary and recurrent condition that appears after submersion in water, known as the bhand in the bucket sign,b that gets better within minutes to hours of drying. A less common variant is characterized by persistent lesions that are worsened after water submersion. The cause of aquagenic syringeal acrokeratoderma is unknown, but likely relates to sweating. Several studies have found that it is present in about 40% to 84% of cystic fibrosis patients and also in carriers, which suggest that it may be caused by mutations in the CFTR gene. It is more often found in young women. Besides cystic fibrosis, it is also seen in wasting (marasmus) and nephrotic syndrome and also with the use of aspirin and other drugs such as rofecoxib and celecoxib. In most cases it does not need any treatment and resolves spontaneously. When necessary, it can be treated with topical aluminum chloride or salicylic acid ointment or with tap water iontophoresis. MEDGEN:1789947