disease has feature Hodgkins lymphoma progressive transformation of germinal centers nodular lymphocyte predominant Hodgkin lymphoma https://github.com/monarch-initiative/mondo/issues/9097 https://www.malacards.org/card/nodular_lymphocyte_predominant_hodgkin_lymphoma ONCOTREE:NLPHL nodular lymphocyte-predominant Hodgkin lymphoma GARD:0019079 Orphanet:86893 nodular lymphocyte predominant Hodgkin's lymphoma Hodgkin lymphoma nodular lymphocyte predominant type, NOS ICD10CM:C81.0 icd11.foundation:331115338 Hodgkin lymphoma nodular LP, NOS NCIT:C7258 MONDO:0044778 NLPHL nodular lymphocyte predominant Hodgkin lymphoma UMLS:C1334968 NANDO:1201067 MEDGEN:233758 A monoclonal B-cell neoplasm characterized by a nodular, or a nodular and diffuse proliferation of scattered large neoplastic cells known as popcorn or lymphocyte predominant cells (LP cells)- formerly called L&H cells for lymphocytic and/or histiocytic Reed-Sternberg cell variants. The LP cells lack CD15 and CD30 in nearly all instances. Patients are predominantly male, frequently in the 30-50 year age group. Most patients present with limited stage disease (localized peripheral lymphadenopathy, stage I or II). (WHO 2008)