has material basis in germline mutation in disease has major feature GPAA1 inherited lipid metabolism disorder autosomal recessive disease multiple congenital anomalies/dysmorphic syndrome-intellectual disability developmental anomaly of metabolic origin central nervous system malformation disorder of GPI anchor biosynthesis glycosylphosphatidylinositol biosynthesis defect 15 https://www.malacards.org/card/glycosylphosphatidylinositol_biosynthesis_defect_15 OMIM:617810 GPIBD15 UMLS:C4540520 A rare, genetic, syndromic intellectual disability characterized by global developmental delay, early-onset seizures, cerebellar atrophy, osteopenia, nystagmus and dysmorphic facial features, including bitemporal narrowing, prominent forehead, anteverted nares. Dysarthria, dysmetria, ataxic gait, spasticity and dysmorphic features have also been associated. glycosylphosphatidylinositol biosynthesis defect 15 MEDGEN:1615160 GARD:0017969 MONDO:0060627 Orphanet:529665