tyrosine hydroxylase deficiency TH-deficient progressive infantile encephalopathy 2018-11-10T00:10:46Z https://github.com/monarch-initiative/mondo/issues/7700 tyrosine hydroxylase-deficient progressive infantile encephalopathy MONDO:0100066 A tyrosine hydroxylase deficiency in which individuals are extremely sensitive to levodopa therapy. In this very severe form, treatment with levodopa is often limited by intolerable dyskinesias.