has material basis in germline mutation in RUNX1 hereditary thrombocytopenia and hematologic cancer predisposition syndrome hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1 https://github.com/monarch-initiative/mondo/issues/8567 GARD:0015329 familial platelet syndrome with predisposition to acute myelogenous leukemia This is an autosomal dominant disorder caused by mutations in the RUNX1 gene and is characterized by mild to moderate thrombocytopenia, platelet functional and/or ultrastructural defects and a predisposition to hematologic malignancies, most often AML and MDS, and less frequently T-ALL. hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1 OMIM:601399 FPD/AML syndrome MEDGEN:321945 Familial Platelet Disorder with Associated Myeloid Malignancy FPDMM MONDO:0100083 FPS/AML syndrome familial thrombocytopenia with propensity to acute myelogenous leukemia thrombocytopenia, familial, with propensity to acute myelogenous leukaemia asprin-like platelet disorder NCIT:C151903 familial thrombocytopenia with propensity to acute myelogenous leukaemia NANDO:2200662 platelet disorder, familial, with associated myeloid malignancy familial platelet syndrome with predisposition to acute myelogenous leukaemia thrombocytopenia, familial, with propensity to acute myelogenous leukemia platelet disorder, aspirin-like NORD:1943 UMLS:C1832388 familial platelet disorder with associated myeloid malignancy