has characteristic has characteristic has material basis in germline mutation in APOO X-linked recessive inheritance congenital nervous system disorder inborn mitochondrial myopathy X-linked recessive disease X-linked recessive mitochondrial myopathy GARD:0026061 MONDO:0100138 A mitochondrial myopathy caused by defects in the MICOS subunit gene APOO (MIC26). Modelling in yeast and flies demonstrate an inability to insert MICOS complex into the inner mitohondrial membrane. Associated symptoms include, lactic acidosis, cognitive impairment and autistic features. X-linked recessive mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features hereditary neuromuscular disease