has material basis in germline mutation in predisposes towards DICER1 syndromic disease hereditary disease cancer DICER1-related tumor predisposition https://github.com/monarch-initiative/mondo/issues/6460 https://rarediseases.info.nih.gov/diseases/10734/dicer1-related-pleuropulmonary-blastoma-cancer-predisposition-syndrome https://www.malacards.org/card/dicer1_syndrome https://www.malacards.org/card/dicer1_tumor_predisposition SCTID:702411003 DOID:0081063 Orphanet:284343 MEDGEN:825667 ICD9:199.1 NCIT:C123317 MONDO:0100216 DICER1-related pleuropulmonary blastoma pleuropulmonary blastoma familial tumour susceptibility syndrome PPB familial tumour susceptibility syndrome https://github.com/monarch-initiative/mondo/issues/5779 DICER1-related pleuropulmonary blastoma cancer predisposition syndrome PPBFTDS Pathogenic germline variation in DICER1 confers an autosomal dominant predisposition to tumor formation at multiple primary sites, including pleuropulmonary blastoma, pulmonary cysts, thyroid gland neoplasia, ovarian tumors, and cystic nephroma. Other syndromic features such as macrocephaly have been described. UMLS:C3839822 pleuro-pulmonary blastoma familial tumour susceptibility syndrome GARD:0010734 DICER1 syndrome