has material basis in germline mutation in NARS1 autosomal recessive disease neurodevelopmental disorder with microcephaly, impaired language, and gait abnormalities https://github.com/monarch-initiative/mondo/issues/3680 https://github.com/monarch-initiative/mondo/issues/4521 https://github.com/monarch-initiative/mondo/issues/5167 https://www.malacards.org/card/neurodevelopmental_disorder_with_microcephaly_impaired_language_and_gait_abnormalities neurodevelopmental disorder with microcephaly, impaired language, and gait abnormalities, autosomal recessive GARD:0018534 OMIM:619091 NEDMILG, AR An autosomal recessive disorder characterized by global developmental delay apparent in infancy. Affected individuals have delayed walking with variable gait abnormalities, impaired intellectual development with poor or absent speech and language, and progressive microcephaly. More variable features include hypotonia, early-onset seizures, and a peripheral demyelinating or axonal peripheral sensorimotor neuropathy. The disease follows a neurodegenerative course in many patients; clinical features suggest involvement of both the central and peripheral nervous systems. MEDGEN:1731507 UMLS:C5436783 MONDO:0100348 Mendelian neurodevelopmental disorder