chronic primary adrenal insufficiency autoimmune primary adrenal insufficiency https://github.com/monarch-initiative/mondo/issues/8485 Addison's disease Diminished production of adrenocortical hormones due to autoimmune destruction of the adrenal glands. autoimmune Addison disease primary Addison's disease autoimmune adrenalitis MONDO:0100480 MEDGEN:543526 This condition is comnonly referred to as Addison disease or Addison's disease. It is also known as autoimmune adrenalitis. It is an acquired primary adrenal insufficiency. Addison disease results from the destruction of the bilateral adrenal cortex, leading to decreased adrenocortical hormones, including cortisol, aldosterone, and androgens. Addison disease's insidious course of action usually presents with glucocorticoid deficiency followed by mineralocorticoid. However, the condition can also present acutely, often triggered by intercurrent illness (MONDO:0019801 acute adrenal insufficiency also called Addisonian crisis). The presentation of adrenal insufficiency depends on the rate and extent of adrenal function involvement. The most common cause of primary adrenal insufficiency is Addison disease, associated with increased levels of 21-hydroxylase antibodies. PMID:28723023. Note the terms "Addison disease" and "Addison's disease" are ambiguous and sometimes are also used to refer to MONDO:0015128 'primary adrenal insufficieny' and MONDO:0015129 'chronic primary adrenal insufficiency'. NCIT:C113814 GARD:0005740 UMLS:C0271737 Addison disease icd11.foundation:1920929898 autoimmune Addison's disease Orphanet:85138 classic Addison's disease