has material basis in germline mutation in predisposes towards CDH1 breast lobular carcinoma hereditary neoplastic syndrome hereditary gastric cancer CDH1-related diffuse gastric and lobular breast cancer syndrome https://github.com/monarch-initiative/mondo/issues/4549 https://github.com/monarch-initiative/mondo/issues/5720 LBC gastric cancer, familial diffuse breast cancer, lobular GARD:0026244 OMIM:137215 gastric cancer, hereditary diffuse HDGC diffuse gastric and lobular breast cancer syndrome Germline pathogenic or likely pathogenic variants in the CDH1 gene predispose to hereditary diffuse gastric cancer, a cancer susceptibility syndrome inherited in an autosomal dominant pattern, initially characterized by the increased risk for diffuse gastric cancer (DGC) but subsequently well documented to be associated with lobular breast cancer (LBC) in women. DGLBC MONDO:0100488