has material basis in germline mutation in TRAF3 hereditary disease TRAF3 haploinsufficiency https://github.com/monarch-initiative/mondo/issues/6299 MONDO:0100513 Any Mendelian disease in which the cause of the disease is a mutation in the TRAF3 gene. TRAF3 haploinsufficiency caused by heterozygous loss of function (null) variants presents as an immune dysregulation syndrome of recurrent bacterial infections, autoimmunity, systemic inflammation, B cell lymphoproliferation, and hypergammaglobulinemia.