has material basis in germline mutation in TCF7L2 Mendelian neurodevelopmental disorder TCF7L2-related neurodevelopmental disorder https://github.com/monarch-initiative/mondo/issues/10500 https://github.com/monarch-initiative/mondo/issues/6497 A neurodevelopmental disorder caused by a variation in the TCF7L2 gene. This disorder is characterised by speech delay, craniofacial dysmorphism, ophthalmologic conditions including myopia, autism, intellectual disability, attention deficit hyperactivity disorder, and orthopaedic abnormalities. Phenotypic severity is variable and does not cluster by variant type or genomic locus. TCF7L2-related syndrome TRND MONDO:0100525 TCF7L2-related neurodevelopmental disease neurodevelopmental disorder