has material basis in germline mutation in SAMHD1 hereditary disorder of connective tissue SAMHD1-related type 1 interferonopathy https://github.com/monarch-initiative/mondo/issues/7365 Any type 1 interferonopathies in which the cause of the disease is a variation in the SAMHD1 gene. Individuals with variants in SAMHD1 can present with a variety of phenotypes, including Aicardi-Goutieres syndrome and chilblain lupus. MONDO:0700260 GARD:0026403 type 1 interferonopathy