has material basis in germline mutation in BARD1 hereditary neoplastic syndrome BARD1-related cancer predisposition https://github.com/monarch-initiative/mondo/issues/6515 Hereditary cancer predisposition due to variation(s) in the BARD1 gene. Germline pathogenic or likely pathogenic variants in the BARD1 gene confer a moderate risk of breast cancer, inherited in an autosomal dominant pattern, increasingly documented to be specific to triple negative breast cancer in women. BARD1 cancer susceptibility syndrome is also associated with other tumour types including neuroblastoma. MONDO:0700267 GARD:0026407