has material basis in germline mutation in BRCA1 hereditary neoplastic syndrome BRCA1-related cancer predisposition https://github.com/monarch-initiative/mondo/issues/6515 Hereditary cancer predisposition due to variation(s) in the BRCA1 gene. Germline pathogenic or likely pathogenic variants in the BRCA1 gene confer an autosomal dominant predisposition to hereditary breast and ovarian cancer. Tumor formation at other sites, including pancreatic cancer have been described. GARD:0026408 MONDO:0700268