has material basis in germline mutation in CHEK2 hereditary neoplastic syndrome CHEK2-related cancer predisposition https://github.com/monarch-initiative/mondo/issues/6515 UMLS:C5882668 Hereditary cancer predisposition due to variation(s) in the CHEK2 gene. Pathogenic germline variation in CHEK2 confers an autosomal dominant predisposition to tumor formation at multiple primary sites, including breast cancer and prostate cancer. GARD:0026411 MEDGEN:1849727 MONDO:0700271