has material basis in germline mutation in PALB2 hereditary neoplastic syndrome PALB2-related cancer predisposition https://github.com/monarch-initiative/mondo/issues/6515 GARD:0026412 Hereditary cancer predisposition due to variation(s) in the PALB2 gene. Pathogenic germline variation in PALB2 confers an autosomal dominant predisposition to tumor formation at multiple primary sites, including breast cancer, ovarian cancer, and pancreatic cancer. MONDO:0700272