has material basis in germline mutation in RAD51C hereditary neoplastic syndrome RAD51C-related cancer predisposition https://github.com/monarch-initiative/mondo/issues/6515 MONDO:0700273 Hereditary cancer predisposition due to variation(s) in the RAD51C gene. Pathogenic germline variation in RAD51C confers an autosomal dominant predisposition to tumor formation at multiple primary sites, including ovarian cancer, triple negative breast cancer and ER negative breast cancer. GARD:0026413