has material basis in germline mutation in ARF3 Mendelian neurodevelopmental disorder ARF3-related neurodevelopmental disorder https://github.com/monarch-initiative/mondo/issues/9633 A neurodevelopmental disorder caused by variation in the ARF3 gene. This disorder is characterised by intellectual disability, delayed or absent speech, motor development delay, and brain MRI abnormalitites. Other phenotypes observed less frequently include seizures, hypotonia, acquired microcephaly, dysmorphic features, and cardiac abnormalities. MONDO:0700366